Indonesian Journal of Chemistry (Jun 2010)

SYNTHESIS OF SAFRYL KETONE FROM SAFROLE

  • Hanoch J Sohilait,
  • Hardjono Sastrohamidjojo,
  • Sabirin Matsjeh,
  • J Stuart Grossert

DOI
https://doi.org/10.22146/ijc.21874
Journal volume & issue
Vol. 4, no. 1
pp. 58 – 61

Abstract

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Synthesis of safryl ketone from safrole has been achieved through conversion of allyl group to secondary alcohol, followed by oxidation with PCC-Al2O3. The oxymecuration-demercuration reaction of safrole with HgSO4-NaBH4 yields safryl alcohol (66.38%) and the oxidation of safryl alcohol with PCC-Al2O3 yields safryl ketone (62.92%). The structure elucidation of these products was conducted using Fourier Transformed Infra Red Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) and Mass Spectroscopy (MS). Keywords: safryl ketone, safrole