Reproducibility of preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula

Volk Andreas; Distler Marius; Müssle Benjamin; Berning Marco; Hampe Jochen; Brückner Stefan; Weitz Jürgen; Welsch Thilo

doi:10.1515/iss-2017-0040

Innovative Surgical Science (Jan 2018)

Reproducibility of preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula

Volk Andreas,
Distler Marius,
Müssle Benjamin,
Berning Marco,
Hampe Jochen,
Brückner Stefan,
Weitz Jürgen,
Welsch Thilo

Affiliations

Volk Andreas: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Distler Marius: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Müssle Benjamin: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Berning Marco: Department of Internal Medicine, Section of Gastroenterology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Hampe Jochen: Department of Internal Medicine, Section of Gastroenterology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Brückner Stefan: Department of Internal Medicine, Section of Gastroenterology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Weitz Jürgen: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
Welsch Thilo: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Dresden, Fetscherstraße 74, 01307 Dresden, Germany

DOI: https://doi.org/10.1515/iss-2017-0040
Journal volume & issue: Vol. 3, no. 1
pp. 69 – 75

Abstract

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A postoperative pancreatic fistula (POPF) is the most common and potentially life-threatening surgical complication in pancreatic surgery. One possible pharmacological treatment could be the endoscopic injection of botulinum toxin (BTX) into the sphincter of Oddi to prevent POPF. Promising data reported a significantly reduced rate of clinically relevant POPF. We analyzed the effect of BTX injection in our patients undergoing distal pancreatectomy (DP).

Published in Innovative Surgical Science

ISSN: 2364-7485 (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Medicine: Surgery
Website: https://www.degruyter.com/journal/key/iss/html

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