Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

Abdullah Khamis Ali Al Saidi; Adibehalsadat Ghazanfari; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Dejun Zhao; Ying Liu; So Hyeon Yang; Dong Wook Hwang; Ji-ung Yang; Ji Ae Park; Jae Chang Jung; Sung-Wook Nam; Yongmin Chang; Gang Ho Lee

doi:10.3390/nano13050806

Nanomaterials (Feb 2023)

Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

Abdullah Khamis Ali Al Saidi,
Adibehalsadat Ghazanfari,
Shuwen Liu,
Tirusew Tegafaw,
Mohammad Yaseen Ahmad,
Dejun Zhao,
Ying Liu,
So Hyeon Yang,
Dong Wook Hwang,
Ji-ung Yang,
Ji Ae Park,
Jae Chang Jung,
Sung-Wook Nam,
Yongmin Chang,
Gang Ho Lee

Affiliations

Abdullah Khamis Ali Al Saidi: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Adibehalsadat Ghazanfari: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Shuwen Liu: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Tirusew Tegafaw: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Mohammad Yaseen Ahmad: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Dejun Zhao: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Ying Liu: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
So Hyeon Yang: Department of Medical & Biological Engineering, Kyungpook National University, Taegu 41944, Republic of Korea
Dong Wook Hwang: Department of Medical & Biological Engineering, Kyungpook National University, Taegu 41944, Republic of Korea
Ji-ung Yang: Division of RI-Convergence Research, Korea Institute of Radiological & Medical Science, Seoul 01817, Republic of Korea
Ji Ae Park: Division of RI-Convergence Research, Korea Institute of Radiological & Medical Science, Seoul 01817, Republic of Korea
Jae Chang Jung: Department of Biology, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea
Sung-Wook Nam: Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea
Yongmin Chang: Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea
Gang Ho Lee: Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea

DOI: https://doi.org/10.3390/nano13050806
Journal volume & issue: Vol. 13, no. 5
p. 806

Abstract

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Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using a one-pot polyol method. Their physicochemical and X-ray attenuation properties were characterized. All polymer-coated Pt-NPs had an average particle diameter (davg) of 2.0 nm. Polymers grafted onto Pt-NP surfaces exhibited excellent colloidal stability (i.e., no precipitation after synthesis for >1.5 years) and low cellular toxicity. The X-ray attenuation power of the polymer-coated Pt-NPs in aqueous media was stronger than that of the commercial iodine contrast agent Ultravist at the same atomic concentration and considerably stronger at the same number density, confirming their potential as computed tomography contrast agents.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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