The Experience of Application of <i>Yersinia pestis</i> Antigens for Plague Chemical Vaccine Development

Abstract

The review presents data on history and current status of the problem of chemical plague vaccine development Literature data about protective activity of some Yersinia pestis monoantigens as well as immunogenic properties of complex antigen preparations are summarized. The possibility and expediency of development of the appropriate vaccine preparations are evaluated, including their potential role and significance for the specific plague prophylaxis as the anti-epidemic measure.

Keywords

• plague
• chemical vaccine
• antigen
• protective activity
• immunization