Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Eduardo Pinho Melo; Tasuku Konno; Ilaria Farace; Mosab Ali Awadelkareem; Lise R. Skov; Fernando Teodoro; Teresa P. Sancho; Adrienne W. Paton; James C. Paton; Matthew Fares; Pedro M. R. Paulo; Xin Zhang; Edward Avezov

doi:10.1038/s41467-022-30238-2

Nature Communications (May 2022)

Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Eduardo Pinho Melo,
Tasuku Konno,
Ilaria Farace,
Mosab Ali Awadelkareem,
Lise R. Skov,
Fernando Teodoro,
Teresa P. Sancho,
Adrienne W. Paton,
James C. Paton,
Matthew Fares,
Pedro M. R. Paulo,
Xin Zhang,
Edward Avezov

Affiliations

Eduardo Pinho Melo: Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge
Tasuku Konno: Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge
Ilaria Farace: Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge
Mosab Ali Awadelkareem: Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge
Lise R. Skov: Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge
Fernando Teodoro: CCMAR-Centro de Ciências do Mar, Universidade do Algarve, Campus de Gambelas
Teresa P. Sancho: CCMAR-Centro de Ciências do Mar, Universidade do Algarve, Campus de Gambelas
Adrienne W. Paton: Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide
James C. Paton: Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide
Matthew Fares: Department of Chemistry, The Pennsylvania State University, University Park
Pedro M. R. Paulo: Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais
Xin Zhang: Department of Chemistry, The Pennsylvania State University, University Park
Edward Avezov: Department of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge

DOI: https://doi.org/10.1038/s41467-022-30238-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Aggregation of misfolded proteins underlie dementias. Here, the authors show that stressed cells activate an innate mechanism to resolve aggregates of defective proteins in the endoplasmic reticulum, where a third of cellular proteins are produced.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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