Chorioamnionitis and early pregnancy loss caused by ampicillin-resistant non-typeable Haemophilus influenzae
Yuji Nishihara,
Nobuyasu Hirai,
Takahiro Sekine,
Nao Okuda,
Tomoko Nishimura,
Hiroyuki Fujikura,
Ryutaro Furukawa,
Natsuko Imakita,
Tatsuya Fukumori,
Taku Ogawa,
Yuki Suzuki,
Ryuichi Nakano,
Akiyo Nakano,
Hisakazu Yano,
Kei Kasahara
Affiliations
Yuji Nishihara
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Nobuyasu Hirai
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan; Correspondence to: Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-0813, Japan.
Takahiro Sekine
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Nao Okuda
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Tomoko Nishimura
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Hiroyuki Fujikura
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Ryutaro Furukawa
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Natsuko Imakita
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Tatsuya Fukumori
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Taku Ogawa
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Yuki Suzuki
Department of Microbiology and Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Ryuichi Nakano
Department of Microbiology and Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Akiyo Nakano
Department of Microbiology and Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Hisakazu Yano
Department of Microbiology and Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Kei Kasahara
Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan
Haemophilus influenzae can cause intra-amniotic infection and early pregnancy loss. The mode of transmission and risk factors for H. influenzae uterine cavity infections are unknown. Here, we present the case of chorioamnionitis caused by ampicillin-resistant H. influenzae in a 32-year-old Japanese woman at 16 weeks of gestation. Despite empirical treatment, including ampicillin, as recommended by the current guidelines, she had fetal loss. The antimicrobial regimen was changed to ceftriaxone, and the treatment was completed without complications. Although the prevalence and risk factors for chorioamnionitis caused by ampicillin-resistant H. influenzae are unknown, clinicians need to recognize H. influenzae as a potentially drug-resistant and lethal bacterium for pregnant women.
