فیزیولوژی ورزش و فعالیت بدنی (Feb 2019)

The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats

  • babisan askari,
  • nahid bijeh,
  • amir rashidlamir

DOI
https://doi.org/10.52547/joeppa.12.1.115
Journal volume & issue
Vol. 12, no. 1
pp. 115 – 127

Abstract

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Abstract Purpose: The aim of this study was to determine the effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats. Methods: A total of 28 male Wistar rats were randomly divided into 4 groups; saline injected control (Control), resistance training+saline injected (Training), resistance training+IGF-1 injected (Combined) and IGF-1 injected (Injection). Resistance training protocol consisted of climbing (three days/week, 5 reps/3 sets) a ladder carrying a load suspended from the tail for 8 weeks. IGF-1 and saline (1.5 µg/kg/day) were injected before and after exercise sessions. Three days after the last bout of exercise, colorectal tissues were collected and gene expression levels were analyzed using real-time PCR. Results: In Training, Combined and Injection groups, p53 expression in the colorectal decreased compared with Control (p

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