Shensong yangxin, a multi-functional traditional Chinese medicine for arrhythmia: A review of components, pharmacological mechanisms, and clinical applications
Xuan Lu,
Tongxing Wang,
Bin Hou,
Ningxin Han,
Hongrong Li,
Xiaoqi Wang,
Jingjing Xin,
Yanling He,
Dan Zhang,
Zhenhua Jia,
Cong Wei
Affiliations
Xuan Lu
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Graduate School of Hebei Medical University, 050017, China
Tongxing Wang
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China
Bin Hou
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China
Ningxin Han
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Graduate School of Hebei Medical University, 050017, China
Hongrong Li
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China
Xiaoqi Wang
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050090, Hebei, China
Jingjing Xin
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Graduate School of Hebei Medical University, 050017, China
Yanling He
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050090, Hebei, China
Dan Zhang
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050090, Hebei, China
Zhenhua Jia
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center, Shijiazhuang, 050035, China; Corresponding author. State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China.
Cong Wei
State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang, 050035, China; Hebei Provincial Key Laboratory of Luobing, Shijiazhuang, 050035, China; Corresponding author. No. 238 Tianshan Road, Gaoxin District, Shijiazhuang, Hebei Province, China.
As a common cardiovascular disease (CVD), Arrhythmia refers to any abnormality in the origin, frequency, rhythm, conduction velocity, timing, pathway, sequence, or other aspect of cardiac impulses, and it is one of the common cardiovascular diseases in clinical practice. At present, various ion channel blockers are used for treatment of arrhythmia that include Na+ ion channel blockers, K+ ion channel blockers and Ca2+ ion channel blockers. While these drugs offer benefits, they have led to a gradual increase in drug-related adverse reactions across various systems. As a result, the quest for safe and effective antiarrhythmic drugs is pressing. Recent years have seen some advancements in the treatment of ventricular arrhythmias using traditional Chinese medicine(TCM). The theory of Luobing in TCM has proposed a new drug intervention strategy of ''fast and slow treatment, integrated regulation'' leading to a shift in mindset from ''antiarrhythmic'' to ''rhythm-regulating''. Guided by this theory, the development of Shen Song Yang Xin Capsules (SSYX) has involved various Chinese medicinal ingredients that comprehensively regulate the myocardial electrophysiological mechanism, exerting antiarrhythmic effects on multiple ion channels and non-ion channels. Similarly, in clinical studies, evidence-based research has confirmed that SSYX combined with conventional antiarrhythmic drugs can more effectively reduce the occurrence of arrhythmias. Therefore, this article provides a comprehensive review of the composition and mechanisms of action, pharmacological components, network pharmacology analysis, and clinical applications of SSYX guided by the theory of Luobing, aiming to offer valuable insights for improved clinical management of arrhythmias and related research.
