α-Parvin Expression in Breast Cancer Tissues: Correlation with Clinical Parameters and Prognostic Significance
Midori Takeda,
Hiroaki Ito,
Keisuke Kitahata,
Sota Sato,
Akira Nishide,
Kanae Gamo,
Shunsuke Managi,
Tohru Tezuka,
Akihiko Yoshizawa,
Minsoo Kim
Affiliations
Midori Takeda
Laboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan
Hiroaki Ito
Department of Diagnostic Pathology, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto-shi 606-8507, Kyoto, Japan
Keisuke Kitahata
Laboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan
Sota Sato
Laboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan
Akira Nishide
Laboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan
Kanae Gamo
FIMECS, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa-shi 251-0012, Kanagawa, Japan
Shunsuke Managi
Urban Institute & Department of Civil Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka-shi 819-0395, Fukuoka, Japan
Tohru Tezuka
Laboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan
Akihiko Yoshizawa
Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-cho, Kashihara-shi 634-8521, Nara, Japan
Minsoo Kim
Laboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan
Stromal cells play a critical role in the tumor microenvironment of breast cancer (BC), as they are recruited by tumor cells and regulate the metastatic spread. Though high expression of α-parvin, a member of the parvin family of actin-binding proteins, is reported to be associated with a poor prognosis and metastasis in several cancers, its role in carcinogenesis has not been thoroughly explored. Therefore, we aimed to examine the expression of α-parvin in BC patients by compartmentalizing and quantifying tissues to determine whether α-parvin can be a potential therapeutic target. We performed immunohistochemical (IHC) staining of α-parvin in BC tissues, and the IHC scores were calculated in the overall tissue, stroma, and epithelium using image analysis software. The expression of α-parvin was significantly higher in BC tissues (p = 0.0002) and BC stroma (p < 0.0001) than in normal tissues. Furthermore, all α-parvin scores were significantly positively correlated with the proliferation marker Ki67. The overall and stroma scores are associated with the tumor, (lymph) node, and metastasis (TNM) classification, stage, and grade. These results suggest that high expression of α-parvin in stroma is associated with BCs and might be a new predictive marker for diagnosing BC.
