Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

Zhuo Yafen; Ling Lin; Sun Zhichun; Huang Wensen; Hong Zhenzhen; Zhang Yaping; Peng Xuefeng; Liu Xiaoyu; Yuan Weilan; Xu Wang-Yang; Zhang Yi

doi:10.1515/biol-2021-0019

Open Life Sciences (Feb 2021)

Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China

Zhuo Yafen,
Ling Lin,
Sun Zhichun,
Huang Wensen,
Hong Zhenzhen,
Zhang Yaping,
Peng Xuefeng,
Liu Xiaoyu,
Yuan Weilan,
Xu Wang-Yang,
Zhang Yi

Affiliations

Zhuo Yafen: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China
Ling Lin: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China
Sun Zhichun: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China
Huang Wensen: Department of Internal Medicine, Quanzhou Medical College, Quanzhou, 362300, China
Hong Zhenzhen: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China
Zhang Yaping: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China
Peng Xuefeng: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China
Liu Xiaoyu: Department of Oncology, Quanzhou First Hospital Affiliated to Fuji Medical University, Quanzhou, 362300, China
Yuan Weilan: Department of Information Technology, Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, 201204, China
Xu Wang-Yang: Medical Department, Singlera Genomics Inc., Lane 500, Furonghua Road, Pudong New District, Shanghai, 201318, China
Zhang Yi: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China

DOI: https://doi.org/10.1515/biol-2021-0019
Journal volume & issue: Vol. 16, no. 1
pp. 150 – 159

Abstract

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The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson’s correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90–2.63; P = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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