Nature Communications (Aug 2017)
Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing
- L. Rasche,
- S. S. Chavan,
- O. W. Stephens,
- P. H. Patel,
- R. Tytarenko,
- C. Ashby,
- M. Bauer,
- C. Stein,
- S. Deshpande,
- C. Wardell,
- T. Buzder,
- G. Molnar,
- M. Zangari,
- F. van Rhee,
- S. Thanendrarajan,
- C. Schinke,
- J. Epstein,
- F. E. Davies,
- B. A. Walker,
- T. Meissner,
- B. Barlogie,
- G. J. Morgan,
- N. Weinhold
Affiliations
- L. Rasche
- Myeloma Institute, University of Arkansas for Medical Sciences
- S. S. Chavan
- Myeloma Institute, University of Arkansas for Medical Sciences
- O. W. Stephens
- Myeloma Institute, University of Arkansas for Medical Sciences
- P. H. Patel
- Myeloma Institute, University of Arkansas for Medical Sciences
- R. Tytarenko
- Myeloma Institute, University of Arkansas for Medical Sciences
- C. Ashby
- Myeloma Institute, University of Arkansas for Medical Sciences
- M. Bauer
- Myeloma Institute, University of Arkansas for Medical Sciences
- C. Stein
- Myeloma Institute, University of Arkansas for Medical Sciences
- S. Deshpande
- Myeloma Institute, University of Arkansas for Medical Sciences
- C. Wardell
- Myeloma Institute, University of Arkansas for Medical Sciences
- T. Buzder
- Myeloma Institute, University of Arkansas for Medical Sciences
- G. Molnar
- Myeloma Institute, University of Arkansas for Medical Sciences
- M. Zangari
- Myeloma Institute, University of Arkansas for Medical Sciences
- F. van Rhee
- Myeloma Institute, University of Arkansas for Medical Sciences
- S. Thanendrarajan
- Myeloma Institute, University of Arkansas for Medical Sciences
- C. Schinke
- Myeloma Institute, University of Arkansas for Medical Sciences
- J. Epstein
- Myeloma Institute, University of Arkansas for Medical Sciences
- F. E. Davies
- Myeloma Institute, University of Arkansas for Medical Sciences
- B. A. Walker
- Myeloma Institute, University of Arkansas for Medical Sciences
- T. Meissner
- Department of Molecular and Experimental Medicine, Avera Cancer Institute
- B. Barlogie
- Myeloma Institute, University of Arkansas for Medical Sciences
- G. J. Morgan
- Myeloma Institute, University of Arkansas for Medical Sciences
- N. Weinhold
- Myeloma Institute, University of Arkansas for Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-017-00296-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
In multiple myeloma, malignant cells expand within bone marrow. Here, the authors use multi-region sequencing in patient samples to analyse spatial clonal architecture and heterogeneity, providing novel insight into multiple myeloma progression and evolution.
