Терапевтический архив (Feb 2019)
European registry Helicobacter pylori (Hp-EuReg): how has clinical practice changed in Russia from 2013 to 2018 years
- D S Bordin,
- Yu V Embutnieks,
- L G Vologzhanina,
- T A Ilchishina,
- I N Voynovan,
- A S Sarsenbaeva,
- O V Zaitsev,
- S A Alekseenko,
- R A Abdulkhakov,
- N N Dehnich,
- M F Osipenko,
- M A Livzan,
- V V Tsukanov,
- S G Burkov,
- N V Bakulina,
- E Yu Plotnikova,
- L V Tarasova,
- I V Maev,
- Yu A Kucheryavyi,
- N V Baryshnikova,
- M A Butov,
- S V Kolbasnikov,
- A L Pakhomova,
- T V Zhestkova,
- A Yu Baranovsky,
- S R Abdulhakov,
- E A Ageeva,
- E A Lyalyukova,
- A V Vasyutin,
- N N Golubev,
- I V Savilova,
- L V Morkovkina,
- A G Kononova,
- Francis Megraud,
- Colm O'Morain,
- Mercedes Ramas,
- Olga P Nyssen,
- Adrian G McNicholl,
- Javier P Gisbert
Affiliations
- D S Bordin
- A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow
- Yu V Embutnieks
- A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow
- L G Vologzhanina
- Gastrocenter
- T A Ilchishina
- SM-Clinic
- I N Voynovan
- A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow
- A S Sarsenbaeva
- South Ural State Medical University of the Ministry of Health of the Russian Federation
- O V Zaitsev
- First Clinical Medical Centre
- S A Alekseenko
- Far-Eastern State Medical University of the Ministry of Health of the Russian Federation
- R A Abdulkhakov
- Kazan State Medical University of the Ministry of Health of the Russian Federation
- N N Dehnich
- Smolensk State Medical University of the Ministry of Health of the Russian Federation
- M F Osipenko
- Novosibirsk State Medical University of the Ministry of Health of the Russian Federation
- M A Livzan
- Omsk State Medical University of the Ministry of Health of the Russian Federation
- V V Tsukanov
- Research Institute for Medical Problems of the North
- S G Burkov
- Polyclinic № 3 of the Department for Presidential Affairs of the Russian Federation
- N V Bakulina
- I.I. Mechnikov North-Western State Medical University of the Ministry of Health of the Russian Federation
- E Yu Plotnikova
- Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation
- L V Tarasova
- Republican Gastroenterology Center, Republican Clinical Hospital of the Ministry of Health and Social Development of Chuvashia; I.N. Ulyanov Chuvash State University
- I V Maev
- A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation
- Yu A Kucheryavyi
- A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation
- N V Baryshnikova
- I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation
- M A Butov
- I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation
- S V Kolbasnikov
- Tver State Medical University of the Ministry of Health of the Russian Federation
- A L Pakhomova
- Saratov State Clinical Hospital №5
- T V Zhestkova
- I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation
- A Yu Baranovsky
- Saint Petersburg State University
- S R Abdulhakov
- Kazan State Medical University of the Ministry of Health of the Russian Federation; Kazan Federal University
- E A Ageeva
- Municipal outpatient clinic №3, Ministry of Health of Khabarovsk Region
- E A Lyalyukova
- Omsk State Medical University of the Ministry of Health of the Russian Federation
- A V Vasyutin
- Research Institute for Medical Problems of the North
- N N Golubev
- Polyclinic № 3 of the Department for Presidential Affairs of the Russian Federation
- I V Savilova
- I.I. Mechnikov North-Western State Medical University of the Ministry of Health of the Russian Federation
- L V Morkovkina
- Republican Gastroenterology Center, Republican Clinical Hospital of the Ministry of Health and Social Development of Chuvashia
- A G Kononova
- Tver State Medical University of the Ministry of Health of the Russian Federation
- Francis Megraud
- Laboratoire de Bactériologie, Hôpital Pellegrin
- Colm O'Morain
- Department of Gastroenterology, Tallaght Hospital/Trinity College Dublin
- Mercedes Ramas
- Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), and Universidad Autónoma de Madrid (UAM)
- Olga P Nyssen
- Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), and Universidad Autónoma de Madrid (UAM)
- Adrian G McNicholl
- Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), and Universidad Autónoma de Madrid (UAM)
- Javier P Gisbert
- Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), and Universidad Autónoma de Madrid (UAM)
- DOI
- https://doi.org/10.26442/00403660.2019.02.000156
- Journal volume & issue
-
Vol. 91,
no. 2
pp. 16 – 24
Abstract
The multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group (EHMSG) is conducted in 27 countries in Europe. The data from the Russian part of the European registry for the management of Helicobacter pylori infection (European Registry on the management of Helicobacter pylori infection, protocol: “Hp-EuReg”) allows us to analyze the real clinical practice of diagnosis and treatment of H. pylori and compare it with international recommendations. Materials and methods. A comparative analysis of the data entered in the register by the Russian research centers “Hp-EuReg”, in the period from 2013 to 2018, was conducted. Results and discussion. Invasive diagnostic methods prevail for the primary diagnosis of H. pylori [histology - 20.3% (in 2013 year) - 43.9% (in 2018 year), rapid urease test - 31.7% and 47.8% respectively]. The most popular mode of eradication therapy is a 10-day triple therapy (62.8-76.2%), the effectiveness of which does not exceed 79% (per protocol). Invasive tests (histology) are the leading method for control the effectiveness of therapy, however, there is a tendency towards a wider use of non-invasive methods (H. pylori stool antigen - from 17% in 2013 to 29.3% in 2018 and urea breath test from 6.9 to 18.3%, respectively). Serological test to control the effectiveness of eradication is still used from 8.2% (2013) to 6.1% (2018). Eradication therapy was not performed in 28% of patients throughout the entire observation period. Conclusion. In Russia, despite approved domestic and international recommendations, deviations in clinical practice persist, both during eradication therapy and in monitoring the effectiveness of eradication therapy.
Keywords