Corrected QT as coronaro-active therapy effectiveness criterion in patients with coronary heart disease and disturbed intraventricular conductivity

Abstract

In total, 76 patients with Functional Class (FC) II-III effort angina and disturbed intraventricular conductivity were divided into three groups, according to intraventricular block localization. Control group included 32 patients with FC II-III effort angina, but without intraventricular block. Dynamic assessment of corrected QT dispersion (dQTc. 24-hour ECG monitoring data) and disturbed local contractility index (DICI. stress echocardiography data) was performed during 2-3-week conservative in-hospital treatment period. Baseline dQTc figures associated with poor prognosis were registered inpatients with right bundle block and anterior left bundle block, with better prognosis in right bundle block. In left bundle block, dQTc was similar to that in patients without intraventricular block. In all groups, there was both baseline and dynamic correlation between dQTc and disturbed local myocardial contractility. Standard conservative treatment resulted in significant dQTc and DICI reduction only inpatients with left bundle block or without any intraventricular blocks.

Keywords

• effort angina
• intraventricular block
• 24jhour ecg monitoring
• corrected qt dispersion
• stress echocarj diography
• disturbed local myocardial contractility