Nature Communications (Jan 2020)
The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
- Mark Pinese,
- Paul Lacaze,
- Emma M. Rath,
- Andrew Stone,
- Marie-Jo Brion,
- Adam Ameur,
- Sini Nagpal,
- Clare Puttick,
- Shane Husson,
- Dmitry Degrave,
- Tina Navin Cristina,
- Vivian F. S. Kahl,
- Aaron L. Statham,
- Robyn L. Woods,
- John J. McNeil,
- Moeen Riaz,
- Margo Barr,
- Mark R. Nelson,
- Christopher M. Reid,
- Anne M. Murray,
- Raj C. Shah,
- Rory Wolfe,
- Joshua R. Atkins,
- Chantel Fitzsimmons,
- Heath M. Cairns,
- Melissa J. Green,
- Vaughan J. Carr,
- Mark J. Cowley,
- Hilda A. Pickett,
- Paul A. James,
- Joseph E. Powell,
- Warren Kaplan,
- Greg Gibson,
- Ulf Gyllensten,
- Murray J. Cairns,
- Martin McNamara,
- Marcel E. Dinger,
- David M. Thomas
Affiliations
- Mark Pinese
- Garvan Institute of Medical Research
- Paul Lacaze
- Department of Epidemiology and Preventive Medicine, Monash University
- Emma M. Rath
- Garvan Institute of Medical Research
- Andrew Stone
- Garvan Institute of Medical Research
- Marie-Jo Brion
- Garvan Institute of Medical Research
- Adam Ameur
- Department of Epidemiology and Preventive Medicine, Monash University
- Sini Nagpal
- Center for Integrative Genomics, Georgia Institute of Technology
- Clare Puttick
- Garvan Institute of Medical Research
- Shane Husson
- Garvan Institute of Medical Research
- Dmitry Degrave
- Garvan Institute of Medical Research
- Tina Navin Cristina
- Sax Institute
- Vivian F. S. Kahl
- Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
- Aaron L. Statham
- Garvan Institute of Medical Research
- Robyn L. Woods
- Department of Epidemiology and Preventive Medicine, Monash University
- John J. McNeil
- Department of Epidemiology and Preventive Medicine, Monash University
- Moeen Riaz
- Department of Epidemiology and Preventive Medicine, Monash University
- Margo Barr
- Centre for Primary Health Care and Equity, University of New South Wales
- Mark R. Nelson
- Department of Epidemiology and Preventive Medicine, Monash University
- Christopher M. Reid
- Department of Epidemiology and Preventive Medicine, Monash University
- Anne M. Murray
- Berman Center for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare
- Raj C. Shah
- Department of Family Medicine and Rush Alzheimer’s Disease Center, Rush University Medical Center
- Rory Wolfe
- Department of Epidemiology and Preventive Medicine, Monash University
- Joshua R. Atkins
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Chantel Fitzsimmons
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Heath M. Cairns
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Melissa J. Green
- School of Psychiatry, University of New South Wales
- Vaughan J. Carr
- School of Psychiatry, University of New South Wales
- Mark J. Cowley
- Garvan Institute of Medical Research
- Hilda A. Pickett
- Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
- Paul A. James
- Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre
- Joseph E. Powell
- UNSW Cellular Genomics Futures Institute, School of Medical Sciences, University of New South Wales
- Warren Kaplan
- Garvan Institute of Medical Research
- Greg Gibson
- Center for Integrative Genomics, Georgia Institute of Technology
- Ulf Gyllensten
- Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University
- Murray J. Cairns
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Martin McNamara
- Sax Institute
- Marcel E. Dinger
- Garvan Institute of Medical Research
- David M. Thomas
- Garvan Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-019-14079-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Healthspan and healthy aging are areas of research with potential socioeconomic impact. Here, the authors present the Medical Genome Reference Bank (MGRB) which consist of over 4,000 individuals aged 70 years and older without a history of the major age-related diseases and report on results from whole-genome sequencing and association analyses.
