Leukemia Research Reports (Jan 2018)
Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry
- Aya Nakaya,
- Hideo Yagi,
- Hitomi Kaneko,
- Satoru Kosugi,
- Toru Kida,
- Yoko Adachi,
- Hirohiko Shibayama,
- Takae Kohara,
- Yuri Kamitsuji,
- Shin-ichi Fuchida,
- Nobuhiko Uoshima,
- Eri Kawata,
- Hitoji Uchiyama,
- Yuji Shimura,
- Takayuki Takahashi,
- Fumiaki Urase,
- Kensuke Ohta,
- Tsuneyoshi Hamada,
- Kazue Miyamoto,
- Masayuki Kobayashi,
- Maki Shindo,
- Hirokazu Tanaka,
- Chihiro Shimazaki,
- Masayuki Hino,
- Junya Kuroda,
- Yuzuru Kanakura,
- Akifumi Takaoari-Kondo,
- Shosaku Nomura,
- Itaru Matsumura
Affiliations
- Aya Nakaya
- First Department of Internal Medicine, Kansai Medical University, Japan; Kansai Myeloma Forum, Japan; Corresponding author at: First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi-City, Osaka 570-8507, Japan.
- Hideo Yagi
- Department of Hematology, Nara Hospital, Kindai University School of Medicine, Japan; Kansai Myeloma Forum, Japan
- Hitomi Kaneko
- Japanese Red Cross Osaka Hospital, Department of Hematology, Japan; Kansai Myeloma Forum, Japan
- Satoru Kosugi
- Department of Internal Medicine (Hematology), Toyonaka Municipal Hospital, Japan; Kansai Myeloma Forum, Japan
- Toru Kida
- Department of Internal Medicine (Hematology), Toyonaka Municipal Hospital, Japan; Kansai Myeloma Forum, Japan
- Yoko Adachi
- JCHO Kobe Central Hospital, Department of Internal Medicine, Japan; Kansai Myeloma Forum, Japan
- Hirohiko Shibayama
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Japan; Kansai Myeloma Forum, Japan
- Takae Kohara
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Japan; Kansai Myeloma Forum, Japan
- Yuri Kamitsuji
- Department of Hematology, Matsushita Memorial Hospital, Japan; Kansai Myeloma Forum, Japan
- Shin-ichi Fuchida
- Japan Community Health care Organization Kyoto Kuramaguchi Medical Center, Department of Hematology, Japan; Kansai Myeloma Forum, Japan
- Nobuhiko Uoshima
- Japanese Red Cross Kyoto Daini Hospital, Department of Hematology, Japan; Kansai Myeloma Forum, Japan
- Eri Kawata
- Japanese Red Cross Kyoto Daini Hospital, Department of Hematology, Japan; Kansai Myeloma Forum, Japan
- Hitoji Uchiyama
- Kansai Myeloma Forum, Japan
- Yuji Shimura
- Kansai Myeloma Forum, Japan
- Takayuki Takahashi
- Kansai Myeloma Forum, Japan
- Fumiaki Urase
- Kansai Myeloma Forum, Japan
- Kensuke Ohta
- Kansai Myeloma Forum, Japan
- Tsuneyoshi Hamada
- Kansai Myeloma Forum, Japan
- Kazue Miyamoto
- Kansai Myeloma Forum, Japan
- Masayuki Kobayashi
- Kansai Myeloma Forum, Japan
- Maki Shindo
- Kansai Myeloma Forum, Japan
- Hirokazu Tanaka
- Kansai Myeloma Forum, Japan
- Chihiro Shimazaki
- Kansai Myeloma Forum, Japan
- Masayuki Hino
- Kansai Myeloma Forum, Japan
- Junya Kuroda
- Kansai Myeloma Forum, Japan
- Yuzuru Kanakura
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Japan; Kansai Myeloma Forum, Japan
- Akifumi Takaoari-Kondo
- Kansai Myeloma Forum, Japan
- Shosaku Nomura
- First Department of Internal Medicine, Kansai Medical University, Japan; Kansai Myeloma Forum, Japan
- Itaru Matsumura
- Kansai Myeloma Forum, Japan
- Journal volume & issue
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Vol. 10
pp. 7 – 10
Abstract
We retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum. Twenty patients received novel agents (bortezomib or lenalidomide), and their median survival of was 34 months. The median survival of patients who underwent autologous stem cell transplantation (SCT) was 40 months, those undergoing allogeneic SCT 55 months, and those undergoing both types of SCT (auto–allo) 61 months; whereas for those who did not undergo SCT it was 28 months (p = 0.845). The only statistically significant risk factor identified by multivariate analysis was hypercalcemia. Keywords: Primary plasma cell leukemia, Novel agent, Hypercalcemia, Stem cell transplantation
