International Journal of Nanomedicine (Sep 2022)
A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis
Abstract
Qixiong Zhang1 *, Shanshan Li2 *, Yang Yu,3 Yuxuan Zhu,1 Rongsheng Tong1 1Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, People’s Republic of China; 2College of Pharmacy, Southwest Minzu University, Chengdu, 610000, People’s Republic of China; 3College of Pharmaceutical Sciences, Southwest University, Chongqing, 400712, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qixiong Zhang, Department of Pharmacy, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610000, People’s Republic of China, Email [email protected]: Pancreatitis is an inflammatory reaction of pancreatic tissue digestion, edema, bleeding and even necrosis caused by activation of pancreatin due to various causes. In particular, patients with severe acute pancreatitis (SAP) often suffer from secondary infection, peritonitis and shock, and have a high mortality rate. Chronic pancreatitis (CP) can cause permanent damage to the pancreas. Due to the innate characteristics, structure and location of the pancreas, there is no effective treatment, only relief of symptoms. Especially, AP is an unpredictable and potentially fatal disease, and the timely diagnosis and treatment remains a major challenge. With the rapid development of nanomedicine technology, many potential tools can be used to address this problem. In this review, we have introduced the pathophysiological processes of pancreatitis to understanding its etiology and severity. Most importantly, the current progress in the diagnosis and treatment tools of pancreatitis based on nanomedicine is summarized and prospected.Graphical Abstract: Keywords: pancreatitis, nanomedicine, diagnosis, therapy
