PHARMACEUTICAL CORRECTION OF VASCULAR DISTURBANCES IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

Aim: To study vascular stiffness and elasticity, microcirculation (MC) parameters, and mildronate effects in patients with arterial hypertension (AH). Material and methods. The study included 99 patients with Stage I-II AH (mean age 63,2+2,6 years). Pulse wave velocity was assessed by volume sphygmography (Poly-Spectre system, Neuro-Soft). MC parameters were assessed with a computerised Doppler ultrasound device (Minimax-Doppler-K). After a wash-out period, the participants were randomised into 2 groups. Group I received enalapril (Renipril, Pharmstandard; 10 mg/d) and mildronate (0,25 g twice a day). Group II was administered Renipril (10 mg/d) only. Results. After 12 weeks of the treatment, blood pressure (BP) levels were significantly reduced. In Group I, a significant increase in mean linear blood flow velocity after occlusion test, as well as in volume blood flow velocity, was observed, compared to the baseline. In 66% of the patients, blood flow velocity after occlusion test was increased by at least 20%. Conclusion. Adding mildronate to the standard antihypertensive therapy with ACE inhibitors facilitates faster normalisation of vascular function.

Keywords

• arterial hypertension
• vascular disturbances
• cardioprotection