Nature Communications (Feb 2020)
Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis
- Lichan Tu,
- Ping Su,
- Zhongren Zhang,
- Linhui Gao,
- Jiadian Wang,
- Tianyuan Hu,
- Jiawei Zhou,
- Yifeng Zhang,
- Yujun Zhao,
- Yuan Liu,
- Yadi Song,
- Yuru Tong,
- Yun Lu,
- Jian Yang,
- Cao Xu,
- Meirong Jia,
- Reuben J. Peters,
- Luqi Huang,
- Wei Gao
Affiliations
- Lichan Tu
- School of Traditional Chinese Medicine, Capital Medical University
- Ping Su
- State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Zhongren Zhang
- Novogene Bioinformatics Institute
- Linhui Gao
- School of Traditional Chinese Medicine, Capital Medical University
- Jiadian Wang
- School of Traditional Chinese Medicine, Capital Medical University
- Tianyuan Hu
- School of Traditional Chinese Medicine, Capital Medical University
- Jiawei Zhou
- School of Traditional Chinese Medicine, Capital Medical University
- Yifeng Zhang
- School of Traditional Chinese Medicine, Capital Medical University
- Yujun Zhao
- State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Yuan Liu
- School of Traditional Chinese Medicine, Capital Medical University
- Yadi Song
- School of Traditional Chinese Medicine, Capital Medical University
- Yuru Tong
- State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Yun Lu
- School of Traditional Chinese Medicine, Capital Medical University
- Jian Yang
- State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Cao Xu
- University of Chinese Academy of Sciences
- Meirong Jia
- Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University
- Reuben J. Peters
- Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology, Iowa State University
- Luqi Huang
- State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences
- Wei Gao
- School of Traditional Chinese Medicine, Capital Medical University
- DOI
- https://doi.org/10.1038/s41467-020-14776-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Tripterygium wilfordii is a medical plant that can produce antitumor activity compound triptolide. Here, the authors assemble its genome and identify a cytochrome P450 that can catalyze oxidation of a methyl to the acid moiety of dehydroabietic acid in triptolide biosynthesis by integrating multi-omics data.
