Establishment of a core outcome set for burn care research: development and international consensus
Nukhba Zia,
Chris Metcalfe,
Jonathan Mathers,
Zephanie Tyack,
Anna Davies,
Sian Falder,
Baljit Dheansa,
Amber Young,
Sara Brookes,
Fiona Wood,
Jo Dumville,
Jamie Kirkham,
Tom Potokar,
Carmen Tsang,
Dale Edgar,
Nicole Gibran,
Jill Meirte,
Teruichi Harada,
Rajeev Ahuja,
Sarah Gaskell,
Sarah Smailes,
Marc Jeschke,
Murat Ali Cinar,
Amr Moghazy,
Jane Mary Blazeby
Affiliations
Nukhba Zia
Johns Hopkins International Injury Research Unit, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Chris Metcalfe
Bristol Trials Centre, University of Bristol, Bristol, UK
Jonathan Mathers
Institute of Applied Health Research, University of Birmingham, Birmingham, UK
Zephanie Tyack
Child Health Research Centre, Faculty of Medicine, Centre for Children’s Burns and Trauma Research, Queensland University of Technology, Brisbane, QLD, Australia
Anna Davies
3 Centre for Academic Child Health, University of Bristol, Bristol, UK
Sian Falder
Department of plastic surgery, Alder Hey Children`s NHS Foundation Trust, Liverpool, UK
Baljit Dheansa
Department of plastic surgery and burns, Queen Victoria Hospital, East Grinstead, UK
Amber Young
1University of Michigan, Ann Arbor, United States of America
Sara Brookes
Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK
Fiona Wood
Burn service, University of Western Australia, Perth, WA, Australia
Jo Dumville
Division of Population Health, Health Services Research & Primary Care, University of Manchester, Manchester, UK
Jamie Kirkham
Centre for Biostatistics, The University of Manchester, Manchester, UK
Tom Potokar
Centre for Global Burn Injury Policy and Research, Swansea University, Swansea, UK
Carmen Tsang
Centre for Surgical Research, Population Health Sciences, Bristol Biomedical Research Centre, Bristol Medical School, University of Bristol, Bristol, UK
Dale Edgar
Adult Burns Unit, Fiona Stanley Hospital, Murdoch, WA, Australia
Nicole Gibran
UW Medicine Regional Burn Center, Harborview Medical Center, UW Department of Surgery, University of Washington (UW), Seattle, WA, USA
Jill Meirte
Department of Medicine and Health Sciences, University of Antwerp, Antwerpen, Belgium
Teruichi Harada
Seitokai Medical and Social Welfare Corporation, Teramoto Memorial Hospital, Kawachinagano, Osaka, Japan
Rajeev Ahuja
Department of Burns & Plastic Surgery, Lok Nayak Hospital and Maulana Azad Medical College, New Delhi, India
Sarah Gaskell
Paediatric Psychosocial Service, Royal Manchester Children`s Hospital, Manchester, UK
Sarah Smailes
Department of physiontherapy, Broomfield Hospital, Mid Essex Hospitals, Chelmsford, UK
Marc Jeschke
Department of Surgery and Plastic Surgery, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada
Murat Ali Cinar
Department of Physical Therapy and Rehabilitation, Hasan Kalyoncu University, Gaziantep, Turkey
Amr Moghazy
Department of plastic surgery, Suez Canal University, Ismailia, Egypt
Jane Mary Blazeby
Centre for Surgical Research, Population Health Sciences, Bristol Biomedical Research Centre, Bristol Medical School, University of Bristol, Bristol, UK
Objective To develop a core outcome set for international burn research.Design Development and international consensus, from April 2017 to November 2019.Methods Candidate outcomes were identified from systematic reviews and stakeholder interviews. Through a Delphi survey, international clinicians, researchers, and UK patients prioritised outcomes. Anonymised feedback aimed to achieve consensus. Pre-defined criteria for retaining outcomes were agreed. A consensus meeting with voting was held to finalise the core outcome set.Results Data source examination identified 1021 unique outcomes grouped into 88 candidate outcomes. Stakeholders in round 1 of the survey, included 668 health professionals from 77 countries (18% from low or low middle income countries) and 126 UK patients or carers. After round 1, one outcome was discarded, and 13 new outcomes added. After round 2, 69 items were discarded, leaving 31 outcomes for the consensus meeting. Outcome merging and voting, in two rounds, with prespecified thresholds agreed seven core outcomes: death, specified complications, ability to do daily tasks, wound healing, neuropathic pain and itch, psychological wellbeing, and return to school or work.Conclusions This core outcome set caters for global burn research, and future trials are recommended to include measures of these outcomes.
