Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration

Renza Spelat; Federico Ferro; Paolo Contessotto; Amal Aljaabary; Sergio Martin-Saldaña; Chunsheng Jin; Niclas G. Karlsson; Maura Grealy; Markus M. Hilscher; Fulvio Magni; Clizia Chinello; Michelle Kilcoyne; Abhay Pandit

doi:10.1038/s42003-022-04328-2

Communications Biology (Dec 2022)

Metabolic reprogramming and membrane glycan remodeling as potential drivers of zebrafish heart regeneration

Renza Spelat,
Federico Ferro,
Paolo Contessotto,
Amal Aljaabary,
Sergio Martin-Saldaña,
Chunsheng Jin,
Niclas G. Karlsson,
Maura Grealy,
Markus M. Hilscher,
Fulvio Magni,
Clizia Chinello,
Michelle Kilcoyne,
Abhay Pandit

Affiliations

Renza Spelat: CÚRAM, SFI Research Centre for Medical Devices, University of Galway
Federico Ferro: CÚRAM, SFI Research Centre for Medical Devices, University of Galway
Paolo Contessotto: CÚRAM, SFI Research Centre for Medical Devices, University of Galway
Amal Aljaabary: CÚRAM, SFI Research Centre for Medical Devices, University of Galway
Sergio Martin-Saldaña: CÚRAM, SFI Research Centre for Medical Devices, University of Galway
Chunsheng Jin: Department of Medical Biochemistry, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Niclas G. Karlsson: Department of Medical Biochemistry, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Maura Grealy: Pharmacology and Therapeutics, School of Medicine, University of Galway
Markus M. Hilscher: Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
Fulvio Magni: Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca
Clizia Chinello: Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca
Michelle Kilcoyne: CÚRAM, SFI Research Centre for Medical Devices, University of Galway
Abhay Pandit: CÚRAM, SFI Research Centre for Medical Devices, University of Galway

DOI: https://doi.org/10.1038/s42003-022-04328-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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Transcriptomic and proteomic analyses reveal that glycosylation and carbohydrate metabolism are central processes in heart regeneration in zebrafish, including a shift from OXPHOS to glycolysis seven days after injury.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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