LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

Da-Hye Lee; Jae Oh Park; Tae-Shin Kim; Sang-Kyum Kim; Tack-hoon Kim; Min-chul Kim; Gun Soo Park; Jeong-Hwan Kim; Shinji Kuninaka; Eric N. Olson; Hideyuki Saya; Seon-Young Kim; Ho Lee; Dae-Sik Lim

doi:10.1038/ncomms11961

Nature Communications (Jun 2016)

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

Da-Hye Lee,
Jae Oh Park,
Tae-Shin Kim,
Sang-Kyum Kim,
Tack-hoon Kim,
Min-chul Kim,
Gun Soo Park,
Jeong-Hwan Kim,
Shinji Kuninaka,
Eric N. Olson,
Hideyuki Saya,
Seon-Young Kim,
Ho Lee,
Dae-Sik Lim

Affiliations

Da-Hye Lee: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology
Jae Oh Park: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology
Tae-Shin Kim: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology
Sang-Kyum Kim: Department of Pathology, Yonsei University College of Medicine
Tack-hoon Kim: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology
Min-chul Kim: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology
Gun Soo Park: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology
Jeong-Hwan Kim: Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu
Shinji Kuninaka: Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
Eric N. Olson: Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas
Hideyuki Saya: Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine
Seon-Young Kim: Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu
Ho Lee: National Cancer Center, Graduate School of Cancer Science and Policy, Research Institute
Dae-Sik Lim: National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology

DOI: https://doi.org/10.1038/ncomms11961
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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The Hippo pathway regulates the differentiation of stem and progenitor cells, but it is unclear how it acts in liver development. Here, the authors knockout Hippo pathway components Lats1 and 2in the liver, causing suppression of hepatocyte differentiation but promoting biliary cell differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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