Communications Biology (Sep 2021)

TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia

  • Maren Hülsemann,
  • Colline Sanchez,
  • Polina V. Verkhusha,
  • Vera Des Marais,
  • Serena P. H. Mao,
  • Sara K. Donnelly,
  • Jeffrey E. Segall,
  • Louis Hodgson

DOI
https://doi.org/10.1038/s42003-021-02583-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 23

Abstract

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Hülsemann et al. examine the role of TC10, a p21 small GTPase, in breast cancer invasion and metastasis, by regulating membrane type-1 matrix metalloproteinase (MT1- MMP) at invadopodia. The authors also develop a FRET biosensor for TC10, which is used to further investigate p190RhoGAP-dependent regulation of spatiotemporal TC10 activity.