Kimura disease forming a human polyomavirus 6–negative parotid gland nodule with prominent squamous metaplasia in a young female: A case report

Kenji Yorita, MD, PhD; Tatsuya Fujii, MD; Toshitaka Nagao, MD, PhD; Ichiro Murakami, MD, PhD; Yumiko Hashida, PhD; Tomonori Higuchi, PhD; Masanori Daibata, MD, PhD; Makoto Toi, MD, PhD; Yoshiyuki Ayada, MD; Takuro Igawa, MD, PhD

Radiology Case Reports (May 2023)

Kimura disease forming a human polyomavirus 6–negative parotid gland nodule with prominent squamous metaplasia in a young female: A case report

Kenji Yorita, MD, PhD,
Tatsuya Fujii, MD,
Toshitaka Nagao, MD, PhD,
Ichiro Murakami, MD, PhD,
Yumiko Hashida, PhD,
Tomonori Higuchi, PhD,
Masanori Daibata, MD, PhD,
Makoto Toi, MD, PhD,
Yoshiyuki Ayada, MD,
Takuro Igawa, MD, PhD

Affiliations

Kenji Yorita, MD, PhD: Department of Diagnostic Pathology, Japanese Red Cross Kochi Hospital, 1-4-63-11, Hadaminami-machi, Kochi-shi, Kochi, 780-8562, Japan; Department of Diagnostic Pathology, Kochi University Hospital, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan; Corresponding author.
Tatsuya Fujii, MD: Department of Otorhinolaryngology, JA Kochi Hospital, 526-1, Nakano, Aza, Myouken, Nankoku-shi, Kochi, 783-8509, Japan
Toshitaka Nagao, MD, PhD: Department of Anatomic Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan
Ichiro Murakami, MD, PhD: Department of Diagnostic Pathology, Kochi University Hospital, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan; Department of Pathology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan
Yumiko Hashida, PhD: Department of Microbiology and Infection, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan
Tomonori Higuchi, PhD: Department of Microbiology and Infection, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan
Masanori Daibata, MD, PhD: Department of Microbiology and Infection, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan
Makoto Toi, MD, PhD: Department of Diagnostic Pathology, Kochi University Hospital, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan
Yoshiyuki Ayada, MD: Department of Pathology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan
Takuro Igawa, MD, PhD: Department of Pathology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

Journal volume & issue: Vol. 18, no. 5
pp. 1933 – 1938

Abstract

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A case of an asymptomatic 19-year-old woman with Kimura disease presenting with a nodule in the right parotid gland is presented. She had a medical history of atopic dermatitis and noticed a mass on her right-side neck. Cervical lymphadenopathy was clinically diagnosed. The initial management plan was to observe the lesion, which had enlarged from 1 cm to 2 cm in diameter 6 months later. An excisional biopsy was performed, and the pathology confirmed an eosinophil-containing inflammatory parotid gland lesion with many squamous nests and cysts, mimicking a parotid gland tumor. High serum immunoglobulin E levels, peripheral blood eosinophilia, and pathological and genetic diagnoses confirmed Kimura disease. The lesion tested negative for human polyomavirus 6. No recurrence was observed 15 months after the biopsy. The prognosis of Kimura disease without human polyomavirus 6 infection may be favorable; however, further validation of this hypothesis is required as only 5 or 6 cases of Kimura disease have been evaluated for this viral infection. Proliferative squamous metaplasia occurring in parotid gland lesions of Kimura disease is rare and may complicate the diagnostic imaging and pathological diagnosis.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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