Nature Communications (Jan 2018)
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
- Joseph L. Wiemels,
- Kyle M. Walsh,
- Adam J. de Smith,
- Catherine Metayer,
- Semira Gonseth,
- Helen M. Hansen,
- Stephen S. Francis,
- Juhi Ojha,
- Ivan Smirnov,
- Lisa Barcellos,
- Xiaorong Xiao,
- Libby Morimoto,
- Roberta McKean-Cowdin,
- Rong Wang,
- Herbert Yu,
- Josephine Hoh,
- Andrew T. DeWan,
- Xiaomei Ma
Affiliations
- Joseph L. Wiemels
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Kyle M. Walsh
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Adam J. de Smith
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Catherine Metayer
- School of Public Health, University of California Berkeley
- Semira Gonseth
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Helen M. Hansen
- Department of Neurological Surgery, University of California San Francisco
- Stephen S. Francis
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Juhi Ojha
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Ivan Smirnov
- Department of Neurological Surgery, University of California San Francisco
- Lisa Barcellos
- School of Public Health, University of California Berkeley
- Xiaorong Xiao
- School of Public Health, University of California Berkeley
- Libby Morimoto
- School of Public Health, University of California Berkeley
- Roberta McKean-Cowdin
- Department of Preventative Medicine, University of Southern California
- Rong Wang
- Department of Chronic Diseases Epidemiology, School of Public Health, Yale University
- Herbert Yu
- University of Hawaii Cancer Center
- Josephine Hoh
- Department of Chronic Diseases Epidemiology, School of Public Health, Yale University
- Andrew T. DeWan
- Department of Chronic Diseases Epidemiology, School of Public Health, Yale University
- Xiaomei Ma
- Department of Chronic Diseases Epidemiology, School of Public Health, Yale University
- DOI
- https://doi.org/10.1038/s41467-017-02596-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Childhood acute lymphoblastic leukemia is common in Latino Americans. Here, the authors conduct a genome-wide association study in a Californian cohort containing children of Latino heritage, and identify loci on 17q12 and 8q24 which may affect hematopoietic and growth-regulation pathways.
