Nature Communications (May 2021)

Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis

  • Hongjun Li,
  • Zejun Wang,
  • Zhaowei Chen,
  • Tianyuan Ci,
  • Guojun Chen,
  • Di Wen,
  • Ruoxin Li,
  • Jinqiang Wang,
  • Huan Meng,
  • R. Bryan Bell,
  • Zhifeng Gu,
  • Gianpietro Dotti,
  • Zhen Gu

DOI
https://doi.org/10.1038/s41467-021-22674-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.