An Overview on Immunogenic Cell Death in Cancer Biology and Therapy
Mosar Corrêa Rodrigues,
José Athayde Vasconcelos Morais,
Rayane Ganassin,
Giulia Rosa Tavares Oliveira,
Fabiana Chagas Costa,
Amanda Alencar Cabral Morais,
Ariane Pandolfo Silveira,
Victor Carlos Mello Silva,
João Paulo Figueiró Longo,
Luis Alexandre Muehlmann
Affiliations
Mosar Corrêa Rodrigues
Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil
José Athayde Vasconcelos Morais
Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil
Rayane Ganassin
Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil
Giulia Rosa Tavares Oliveira
Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil
Fabiana Chagas Costa
Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil
Amanda Alencar Cabral Morais
Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil
Ariane Pandolfo Silveira
Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil
Victor Carlos Mello Silva
Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil
João Paulo Figueiró Longo
Laboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil
Luis Alexandre Muehlmann
Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil
Immunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to promote an adaptive immune response against antigens of the dying cell in an immunocompetent host. An important characteristic of ICD is the release and exposure of damage-associated molecular patterns, which are potent endogenous immune adjuvants. As the induction of ICD can be achieved with conventional cytotoxic agents, it represents a potential approach for the immunotherapy of cancer. Here, different aspects of ICD in cancer biology and treatment are reviewed.
