VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin

Michelle J. Nyhan; Shereen M. El Mashad; Tracey R. O’Donovan; Sarfraz Ahmad; Chris Collins; Paul Sweeney; Eamonn Rogers; Gerald C. O’Sullivan; Sharon L. McKenna

doi:10.3233/ACP-CLO-2010-0541

Analytical Cellular Pathology (Jan 2010)

VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin

Michelle J. Nyhan,
Shereen M. El Mashad,
Tracey R. O’Donovan,
Sarfraz Ahmad,
Chris Collins,
Paul Sweeney,
Eamonn Rogers,
Gerald C. O’Sullivan,
Sharon L. McKenna

Affiliations

Michelle J. Nyhan: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland
Shereen M. El Mashad: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland
Tracey R. O’Donovan: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland
Sarfraz Ahmad: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland
Chris Collins: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland
Paul Sweeney: Department of Surgery, Mercy University Hospital, Cork, Ireland
Eamonn Rogers: Department of Surgery, Mercy University Hospital, Cork, Ireland
Gerald C. O’Sullivan: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland
Sharon L. McKenna: Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, Ireland

DOI: https://doi.org/10.3233/ACP-CLO-2010-0541
Journal volume & issue: Vol. 33, no. 3-4
pp. 121 – 132

Abstract

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Background: von Hippel–Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA)IX, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 and osteopontin. pVHL has been characterized in vitro, however, clinical studies are limited. We evaluated the impact of VHL genetic alterations on the expression of several pVHL protein targets in paired normal and tumor tissue.

Published in Analytical Cellular Pathology

ISSN: 2210-7177 (Print); 2210-7185 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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