Toxin import through the antibiotic efflux channel TolC

Nicholas G. Housden; Melissa N. Webby; Edward D. Lowe; Tarick J. El-Baba; Renata Kaminska; Christina Redfield; Carol V. Robinson; Colin Kleanthous

doi:10.1038/s41467-021-24930-y

Nature Communications (Jul 2021)

Affiliations

Nicholas G. Housden: Department of Biochemistry, University of Oxford
Melissa N. Webby: Department of Biochemistry, University of Oxford
Edward D. Lowe: Department of Biochemistry, University of Oxford
Tarick J. El-Baba: Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford
Renata Kaminska: Department of Biochemistry, University of Oxford
Christina Redfield: Department of Biochemistry, University of Oxford
Carol V. Robinson: Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford
Colin Kleanthous: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-24930-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Bacteria can secrete diffusible protein toxins that kill competing bacteria. Here, the authors use biochemical, biophysical and structural analyses to show how one of these toxins exploits TolC (a major antibiotic efflux channel) to transport itself across the outer membrane of target cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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