Perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode: A case report

Fumiya Kutsuna; Yohei Tateishi; Kairi Yamashita; Tadashi Kanamoto; Takuro Hirayama; Tomoaki Shima; Atsushi Nagaoka; Shunsuke Yoshimura; Teiichiro Miyazaki; Jun Sone; Tsuyoshi Izumo; Akira Tsujino

Cerebral Circulation - Cognition and Behavior (Jan 2022)

Perfusion abnormality in neuronal intranuclear inclusion disease with stroke-like episode: A case report

Fumiya Kutsuna,
Yohei Tateishi,
Kairi Yamashita,
Tadashi Kanamoto,
Takuro Hirayama,
Tomoaki Shima,
Atsushi Nagaoka,
Shunsuke Yoshimura,
Teiichiro Miyazaki,
Jun Sone,
Tsuyoshi Izumo,
Akira Tsujino

Affiliations

Fumiya Kutsuna: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan; Department of Neurology, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki, 856-0835, Japan
Yohei Tateishi: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan; Corresponding author at: 1-7-1 Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.
Kairi Yamashita: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Tadashi Kanamoto: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Takuro Hirayama: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Tomoaki Shima: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Atsushi Nagaoka: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Shunsuke Yoshimura: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Teiichiro Miyazaki: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Jun Sone: Department of Neurology, National Hospital Organization Suzuka National Hospital, 3-2-1 Kasado, Suzuka, 513-8501, Mie, Japan; Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan
Tsuyoshi Izumo: Department of Neurosurgery, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan
Akira Tsujino: Department of Neurology and Strokology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

Journal volume & issue: Vol. 3
p. 100127

Abstract

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Neuronal intranuclear inclusion disease (NIID) is a slowly progressive neurodegenerative disease. Some patients with NIID occasionally present with acute symptoms. However, its mechanism remains unclear. We report a patient with NIID who presented with a stroke-like episode. Arterial spin labeling magnetic resonance imaging revealed hypoperfusion in the focal cerebral region at the onset while no apparent arterial occlusion was observed. The abnormal perfusion area was normalized 6 days after admission. Therefore, the perfusion abnormality was likely the main cause of acute neurologic deficits in NIID. NIID should be considered in the differential diagnosis of stroke mimics.

Published in Cerebral Circulation - Cognition and Behavior

ISSN: 2666-2450 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/cerebral-circulation-cognition-and-behavior

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