Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese[S]

Yiwei Ma; Liang Sun; Jun Li; Yao Hu; Zhenji Gan; Geng Zong; He Zheng; Qianlu Jin; Huaixing Li; Frank B. Hu; Rong Zeng; Qi Sun; Xu Lin

Journal of Lipid Research (Feb 2019)

Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese[S]

Yiwei Ma,
Liang Sun,
Jun Li,
Yao Hu,
Zhenji Gan,
Geng Zong,
He Zheng,
Qianlu Jin,
Huaixing Li,
Frank B. Hu,
Rong Zeng,
Qi Sun,
Xu Lin

Affiliations

Yiwei Ma: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
Liang Sun: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
Jun Li: Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115; Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115
Yao Hu: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
Zhenji Gan: The State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China
Geng Zong: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
He Zheng: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
Qianlu Jin: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
Huaixing Li: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China
Frank B. Hu: Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115; Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
Rong Zeng: Shanghai Institute of Nutrition and Health, and Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Department of Life Sciences and Technology, ShanghaiTech University, Shanghai 201210, China
Qi Sun: To whom correspondence should be addressed. (X.L.); (Q.S.); Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
Xu Lin: To whom correspondence should be addressed. (X.L.); (Q.S.); CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Chinese Academy of Sciences, Shanghai 200031, China

Journal volume & issue: Vol. 60, no. 2
pp. 421 – 429

Abstract

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The effects of PUFAs on metabolic syndrome (MetS) remain to be characterized, particularly in Asians. We aimed to investigate the prospective associations of PUFAs with MetS and the role of acylcarnitines in these associations in Chinese individuals. Among 1,245 Chinese men and women aged 50–70 years who completed a 6 year follow-up, baseline erythrocyte FAs and plasma acylcarnitines were profiled using gas chromatography coupled with positive chemical ionization and liquid chromatography-tandem mass spectrometry, respectively. Total n-6 PUFAs and three 22-carbon n-6 PUFAs were significantly associated with lower MetS risk comparing extreme quartiles: relative risks (RRs) (95% CIs) were 0.75 (0.57, 0.97) for total n-6 PUFAs, 0.69 (0.56, 0.85) for 22:2n-6, 0.76 (0.59, 0.99) for 22:4n-6, and 0.74 (0.58, 0.94) for 22:5n-6, while 18:3n-3 and 18:3n-6 were positively associated with MetS risk. In a network analysis, a module mostly consisting of long-chain n-6 PUFAs and very-long-chain saturated FAs was inversely associated with incident MetS (RR per SD: 0.84; 95% CI: 0.76, 0.92), and this module was more strongly associated with lower MetS risk when a short- to medium-chain acylcarnitine (C5–C10) module score was lower (Pinteraction = 0.03). Our data suggested inverse associations of total n-6 and certain long-chain n-6 PUFAs with cardiometabolic disorders, and this association might be modified by certain acylcarnitines.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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