Медицинская иммунология (Apr 2016)

MUCOSAL MICROFLORA AND INNATE IMMUNITY OF UPPER RESPIRATORY TRACT IN INTRAUTERINE FOETAL INFECTION AND PNEUMONIA OF NEONATES

  • O. A. Svitich,
  • S. M. Omarova,
  • A. I. Alieva,
  • N. D. Rasskazova,
  • V. V. Zverev

DOI
https://doi.org/10.15789/1563-0625-2016-2-163-170
Journal volume & issue
Vol. 18, no. 2
pp. 163 – 170

Abstract

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Specific perinatal infections make about 30% in causal structure of infant mortality. Among the respiratory diseases of perinatal period, pneumonias take a special place, due to higher frequency, severity, complications and adverse outcomes. The aim of this work was to study microflora and factors of innate immunity (TLR2, TLR4, HBD-1, HBD-2, TNFα and NF-kB) at the level of the mucous membranes of the upper respiratory tract during intrauterine infection of fetus and perinatal pneumonia. Causal structure of ventilator-associated pneumonias at the intensive care unit represents a broad spectrum of pathogens with high resistance to antibiotics. Changes of immunological parameters (recognizing structures, i.e., TLR2, TLR4, HBD-1; HBD-2 defensins; proinflammatory TNFα cytokine and NF-kB transcription factor) in patients with intrauterine infections and pneumonia are ambiguous. Decreased expression of TLR2, TLR4 genes, along with increased of TNFα and NF-kB gene expression. These changes correlate with type of infectious pathogen, thus allowing us to assume that the pathogen, due to pathogenicity factors, may directly affect innate immunity mechanisms.

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