Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes

Ryuichiro Abe; Yukihiro Akeda; Yo Sugawara; Yuki Matsumoto; Daisuke Motooka; Ryuji Kawahara; Norihisa Yamamoto; Kazunori Tomono; Tetsuya Iida; Shigeyuki Hamada

doi:10.1128/mBio.00186-21

mBio (Jun 2021)

Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes

Ryuichiro Abe,
Yukihiro Akeda,
Yo Sugawara,
Yuki Matsumoto,
Daisuke Motooka,
Ryuji Kawahara,
Norihisa Yamamoto,
Kazunori Tomono,
Tetsuya Iida,
Shigeyuki Hamada

Affiliations

Ryuichiro Abe: Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Yukihiro Akeda: ORCiD; Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Yo Sugawara: ORCiD; Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Yuki Matsumoto: Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Daisuke Motooka: Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Ryuji Kawahara: Department of Microbiology, Osaka Institute of Public Health, Osaka, Japan
Norihisa Yamamoto: Division of Infection Control and Prevention, Osaka University Hospital, Suita, Japan
Kazunori Tomono: Division of Infection Control and Prevention, Osaka University Hospital, Suita, Japan
Tetsuya Iida: Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
Shigeyuki Hamada: Japan-Thailand Research Collaboration Center on Emerging and Re-emerging Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

DOI: https://doi.org/10.1128/mBio.00186-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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We demonstrated the multimerization of plasmids harboring carbapenemase genes, and multimeric plasmids of various discrete sizes existed in a host bacterial cell of Escherichia coli

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal