SAR studies of quinoline and derivatives as potential treatments for Alzheimer’s disease

Abstract

Quinoline analogs are an important class of N-based heterocyclic compounds, which have received extensive attention because of their use in medicinal chemistry and organic synthesis. Over the past few decades, several new scaffold-based functionalization synthesis strategies have been reported for quinolines. Quinoline derivatives have a wide range of biological activities, including anti-Alzheimer’s disease activity. Herein, we review research on quinoline and related analogs as anti-Alzheimer’s disease agents from 2001 to 2022 and particularly highlight the structure–activity relationships and molecular binding modes. This review provides information for the rational design of more effective and target-specific drugs for Alzheimer's disease.

Keywords

• Quinoline
• Anti-Alzheimer
• Multitarget-directed ligand
• Acetylcholinesterase
• Structure–activity relationship
• Neuroprotective activity