Citrin mediated metabolic rewiring in response to altered basal subcellular Ca2+ homeostasis

Abstract

Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca2+ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this process and show that manipulation of Ca2+ dynamics can reprogram cellular and mitochondrial metabolism.