The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition

Soufi Farhad Ghadiri; Zonouzi Ali Akbar Poursadegh; Eftekhar Ebrahim; Kamali Kamila; Chegeni Sara Aghakhani; Zonouzi Ahmad Poursadegh

doi:10.2478/enr-2018-0014

Endocrine Regulations (Jul 2018)

The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition

Soufi Farhad Ghadiri,
Zonouzi Ali Akbar Poursadegh,
Eftekhar Ebrahim,
Kamali Kamila,
Chegeni Sara Aghakhani,
Zonouzi Ahmad Poursadegh

Affiliations

Soufi Farhad Ghadiri: Molecular Medicine Research Center, Hormozgan Health institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Zonouzi Ali Akbar Poursadegh: Department of Genetics and Medical Biotechnology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Eftekhar Ebrahim: Molecular Medicine Research Center, Hormozgan Health institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Kamali Kamila: Larestan University of Medical Sciences, Larestan, Iran
Chegeni Sara Aghakhani: Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Zonouzi Ahmad Poursadegh: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

DOI: https://doi.org/10.2478/enr-2018-0014
Journal volume & issue: Vol. 52, no. 3
pp. 123 – 127

Abstract

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Objectives. It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA expression levels of these genes in the human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition.

Published in Endocrine Regulations

ISSN: 1336-0329 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://sciendo.com/journal/ENR

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Abstract

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