A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

Tetsuro Yoshimaru; Masaya Ono; Yoshimi Bando; Yi-An Chen; Kenji Mizuguchi; Hiroshi Shima; Masato Komatsu; Issei Imoto; Keisuke Izumi; Junko Honda; Yasuo Miyoshi; Mitsunori Sasa; Toyomasa Katagiri

doi:10.1038/ncomms15427

Nature Communications (May 2017)

A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

Tetsuro Yoshimaru,
Masaya Ono,
Yoshimi Bando,
Yi-An Chen,
Kenji Mizuguchi,
Hiroshi Shima,
Masato Komatsu,
Issei Imoto,
Keisuke Izumi,
Junko Honda,
Yasuo Miyoshi,
Mitsunori Sasa,
Toyomasa Katagiri

Affiliations

Tetsuro Yoshimaru: Division of Genome Medicine, Institute for Genome Research, Tokushima University
Masaya Ono: Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute
Yoshimi Bando: Division of Pathology, Tokushima University Hospital
Yi-An Chen: National Institutes of Biomedical Innovation, Health and Nutrition
Kenji Mizuguchi: National Institutes of Biomedical Innovation, Health and Nutrition
Hiroshi Shima: Division of Cancer Chemotherapy, Miyagi Cancer Center Research Institute
Masato Komatsu: Division of Genome Medicine, Institute for Genome Research, Tokushima University
Issei Imoto: Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School
Keisuke Izumi: Department of Molecular and Environmental Pathology, Graduate School of Medicine, Tokushima University Graduate School
Junko Honda: Department of Surgery, National Hospital Organization Higashitokushima Medical Center
Yasuo Miyoshi: Department of Surgery, Division of Breast and Endocrine Surgery, Hyogo College of Medicine
Mitsunori Sasa: Department of Surgery, Tokushima Breast Care Clinic
Toyomasa Katagiri: Division of Genome Medicine, Institute for Genome Research, Tokushima University

DOI: https://doi.org/10.1038/ncomms15427
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal