Children (Mar 2022)

Third-Line Antiretroviral Therapy: What Do We Do When the Appropriate Formulations Are Not Available?

  • Lisa Jane Frigati,
  • Helena Rabie

DOI
https://doi.org/10.3390/children9040473
Journal volume & issue
Vol. 9, no. 4
p. 473

Abstract

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Children on antiretroviral therapy have limited options, particularly if they are failing therapy and live in resource-poor settings. We describe three cases where children accessed third-line antiretroviral therapy off-label, or used them extemporaneously with successful outcomes. We then review the evidence for performing this measure. There is an urgent need for appropriate formulations to treat young children who require a third-line or salvage regimen.

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