THE INFLUENCE OF LEVETIRACTEAM AND DIAZEPAM ON PENICILLIN-INDUCED FOCAL EPILEPTIC ACTIVITY

Abstract

Aim. The power of epileptic foci and their life-span in Wistar rats (44 animals) were investigated under conditions of levetiracetam (30,0 and 130,0 mg/kg, i.p.) and diazepam (0,5 and 1,5 mg/kg, i.p.) treatment in acute experiments. Methods and results. Penicillin – induced (15.000 IU/ml) epileptic foci in rat’s cortex were suppressed by levetiracetam (30,0 and 130 mg/kg, i.p.) with the net reduction of focal epileptic power registered in 120 (by 26,8%) and 30 min (by 48,4 %) from the moment of epileptogen application correspondently. Diazepam (0,5 and 1,5 mg/kg, i.p.) being administered at the height of focal epileptoigenesis, reduced focal activity in 15,0 and 5,0 min by 41,4 and 46,8% correspondently. In 5,0 min from the moment of diazepam administration (1,5 mg/kg, i.p.), which was made after preliminary (in 30 min) treatment with LVR (30,0 mg/kg, i.p.) was followed by 3,7 times reduction of power of focal epileptic activity, when compared with control group (P<0,05). Conclusion. The life-span of focal activity under conditions of combined usage of LVR and diazepam was reduced up to 110,5+11,2 min from 270,5+ 24,5 min in control group (P<0,05).

Keywords

• Diazepam
• Penicillin G
• Anticonvulsants
• Epilepsy