Nature Communications (Nov 2017)
Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum
- Prem Prakash,
- Mohammad Zeeshan,
- Ekta Saini,
- Azhar Muneer,
- Sachin Khurana,
- Bishwanath Kumar Chourasia,
- Arunaditya Deshmukh,
- Inderjeet Kaur,
- Surabhi Dabral,
- Niharika Singh,
- Zille Anam,
- Ayushi Chaurasiya,
- Shikha Kaushik,
- Pradeep Dahiya,
- Md. Kalamuddin,
- Jitendra Kumar Thakur,
- Asif Mohmmed,
- Anand Ranganathan,
- Pawan Malhotra
Affiliations
- Prem Prakash
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Mohammad Zeeshan
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Ekta Saini
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Azhar Muneer
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Sachin Khurana
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Bishwanath Kumar Chourasia
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Arunaditya Deshmukh
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Inderjeet Kaur
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Surabhi Dabral
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Niharika Singh
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Zille Anam
- Special Centre for Molecular Medicine, Jawaharlal Nehru University
- Ayushi Chaurasiya
- Special Centre for Molecular Medicine, Jawaharlal Nehru University
- Shikha Kaushik
- Special Centre for Molecular Medicine, Jawaharlal Nehru University
- Pradeep Dahiya
- Plant Mediator Lab, National Institute of Plant Genome Research
- Md. Kalamuddin
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Jitendra Kumar Thakur
- Plant Mediator Lab, National Institute of Plant Genome Research
- Asif Mohmmed
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Anand Ranganathan
- Recombinant Gene Products Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Pawan Malhotra
- Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- DOI
- https://doi.org/10.1038/s41467-017-01638-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%.
