Journal of Mazandaran University of Medical Sciences (Jan 2005)
Effect of brewer’s yeast supplementation on serum glucose and lipids in type II diabetic patients with dislipidemia
Abstract
Background and purpose : Chromium deficiency leads to impaired glucose and lipid metabolism. Chromium supplementation in type II diabetic patients improves glucose and lipid profiles. Organic chromium, such as found in brewer’s yeast, is much better absorbed than inorganic chromium. In this study, the effect of chromium supplementation in the form of brewer’s yeast on glucose and lipid profile of diabetic patients were evaluated.Materials and methods : In a clinical trial study (before and after) forty (32 women and 8 men) dyslipidemic diabetic patients without liver and cardiovascular diseases, 40-68 years old and BMI ³ 28 were randomly selected. Each patient received brewer’s yeast tablets containing 14.4 microgram chromium per day for 4 and 8 weeks. Fasting blood glucose, total cholesterol, HDL-C, LDLC and triglycerides were measured at the beginning and the end of 4 and 8 weeks after consumption of brewer’s yeast. A 24 hr dietary recall before and 4 and 8 weeks after consumption of brewer’s yeast were analyzed using Nutrition III software. Data were compared using paired t-test and x2-test as appropriate.Results : There were no statistical significant changes in body weight, BMI, energy and macronutrient intake before and after brewer’s yeast tablet. Mean total cholesterol (p<0.05) and fasting blood sugar levels (p<0.04) were significantly decreased after 8 weeks consumption of brewer’s yeast tablets. Mean LDLC and triglyceride level were significantly (p<0.001) decreased after 4 and 8 weeks consumption of brewer’s yeast tablets. Mean HDLC level was significantly (p<0.001) increased after 4 and 8 weeks consumption of brewer’s yeast tablets. An negative relationship was found between total cholesterol, LDLC, HDLC and TG of primary concentration and percentage of changes during study for each parameters.Conclusion : Improved glucose and lipid profile was noted in patients following 4 and 8 weeks consumption of brewer’s yeast tablets containing 14.4 microgram chromium per day. Also low chromium levels in diabetic patients,prevents diabetic patient from cardiovascular disease.
