Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Hiroyasu Kidoya; Fumitaka Muramatsu; Teppei Shimamura; Weizhen Jia; Takashi Satoh; Yumiko Hayashi; Hisamichi Naito; Yuya Kunisaki; Fumio Arai; Masahide Seki; Yutaka Suzuki; Tsuyoshi Osawa; Shizuo Akira; Nobuyuki Takakura

doi:10.1038/s41467-019-09028-w

Nature Communications (Mar 2019)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Hiroyasu Kidoya,
Fumitaka Muramatsu,
Teppei Shimamura,
Weizhen Jia,
Takashi Satoh,
Yumiko Hayashi,
Hisamichi Naito,
Yuya Kunisaki,
Fumio Arai,
Masahide Seki,
Yutaka Suzuki,
Tsuyoshi Osawa,
Shizuo Akira,
Nobuyuki Takakura

Affiliations

Hiroyasu Kidoya: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University
Fumitaka Muramatsu: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University
Teppei Shimamura: Division of Systems Biology, Graduate School of Medicine, Nagoya University
Weizhen Jia: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University
Takashi Satoh: Department of Host Defense, Research Institute for Microbial Diseases, Osaka University
Yumiko Hayashi: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University
Hisamichi Naito: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University
Yuya Kunisaki: Department of Stem Cell Biology and Medicine/Cancer Stem Cell Research, Kyushu University
Fumio Arai: Department of Stem Cell Biology and Medicine/Cancer Stem Cell Research, Kyushu University
Masahide Seki: Department of Medical Genome Sciences Graduate School of Frontier Sciences, The University of Tokyo
Yutaka Suzuki: Department of Medical Genome Sciences Graduate School of Frontier Sciences, The University of Tokyo
Tsuyoshi Osawa: Division of Integrative Nutriomics and Oncology, Research Center for Advanced Science and Technology, The University of Tokyo
Shizuo Akira: Department of Host Defense, Research Institute for Microbial Diseases, Osaka University
Nobuyuki Takakura: Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University

DOI: https://doi.org/10.1038/s41467-019-09028-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Regnase-1 is known to mediate post-trasncriptional regulatory activity through degradation of target mRNAs. Here, the authors show that Regnase-1 regulates self-renewal of haematopoietic stem and progenitor cells through modulation of the stability of Gata2 and Tal1 mRNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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