Nature Communications (Jan 2017)
A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity
- Xiaojie Xu,
- Zhongyi Fan,
- Chaoyang Liang,
- Ling Li,
- Lili Wang,
- Yingchun Liang,
- Jun Wu,
- Shaohong Chang,
- Zhifeng Yan,
- Zhaohui Lv,
- Jing Fu,
- Yang Liu,
- Shuai Jin,
- Tao Wang,
- Tian Hong,
- Yishan Dong,
- Lihua Ding,
- Long Cheng,
- Rui Liu,
- Shenbo Fu,
- Shunchang Jiao,
- Qinong Ye
Affiliations
- Xiaojie Xu
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Zhongyi Fan
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Chaoyang Liang
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Ling Li
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Lili Wang
- Medical Research Center of Shengjing Hospital, China Medical University
- Yingchun Liang
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Jun Wu
- Department of Microorganism Engineering, Beijing Institute of Biotechnology
- Shaohong Chang
- Department of Microorganism Engineering, Beijing Institute of Biotechnology
- Zhifeng Yan
- Department of Gynecology and Obstetrics, PLA General Hospital
- Zhaohui Lv
- Department of Endocrinology, PLA General Hospital
- Jing Fu
- Department of Endocrinology, PLA General Hospital
- Yang Liu
- Department of Thoracic Surgery, PLA General Hospital
- Shuai Jin
- Department of Thoracic Surgery, PLA General Hospital
- Tao Wang
- Department of Oncology, 307 Hospital of People’s Liberation Army
- Tian Hong
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Yishan Dong
- Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute
- Lihua Ding
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Long Cheng
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- Rui Liu
- Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University
- Shenbo Fu
- Department of Radiotherapy, The First Affiliated Hospital of Xi’an Jiao Tong University
- Shunchang Jiao
- Department of Oncology, PLA General Hospital
- Qinong Ye
- Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Collaborative Innovation Center for Cancer Medicine
- DOI
- https://doi.org/10.1038/ncomms14059
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
CDC25 phosphatases are important cell cycle regulators. Here, the authors show that the LIM domain-containing proteins (for example, FHL1) induce inhibitory CDC25 phosphorylation resulting in radioresistance and that a specific peptide can increase tumour radiosensitivity by increasing CDC25 activity.
