Nature Communications (Apr 2020)

Model-driven generation of artificial yeast promoters

  • Benjamin J. Kotopka,
  • Christina D. Smolke

DOI
https://doi.org/10.1038/s41467-020-15977-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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A small set of promoters is used for most genetic construct design in S. cerevisiae. Here, the authors develop a predictive model of promoter activity trained on a data set of over one million sequences and use it to design large sets of high-activity promoters.