Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy

Vincenzo Russo; Luigi Falco; Viviana Tessitore; Alfredo Mauriello; Dario Catapano; Nicola Napolitano; Moiz Tariq; Alfredo Caturano; Giovanni Ciccarelli; Antonello D’Andrea; Antonio Giordano

doi:10.3390/life13091888

Life (Sep 2023)

Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy

Vincenzo Russo,
Luigi Falco,
Viviana Tessitore,
Alfredo Mauriello,
Dario Catapano,
Nicola Napolitano,
Moiz Tariq,
Alfredo Caturano,
Giovanni Ciccarelli,
Antonello D’Andrea,
Antonio Giordano

Affiliations

Vincenzo Russo: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Luigi Falco: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Viviana Tessitore: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Alfredo Mauriello: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Dario Catapano: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Nicola Napolitano: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Moiz Tariq: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Alfredo Caturano: Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Luigi Miraglia 2, 80138 Naples, NA, Italy
Giovanni Ciccarelli: Cardiology Unit, Department of Medical Translational Science, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80126 Naples, NA, Italy
Antonello D’Andrea: Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Luigi Miraglia 2, 80138 Naples, NA, Italy
Antonio Giordano: Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA

DOI: https://doi.org/10.3390/life13091888
Journal volume & issue: Vol. 13, no. 9
p. 1888

Abstract

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Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-associated VTE is complex. In recent years, translational research has intensified, and several studies have highlighted the role of inflammatory cytokines in cancer growth and progression. Simultaneously, the pleiotropic effects of anticoagulants currently recommended for VTE have emerged. In this review, we describe the anti-inflammatory and anticancer effects of both direct oral anticoagulants (DOACs) and low-molecular-weight heparins (LWMHs).

Published in Life

ISSN: 2075-1729 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science
Website: http://www.mdpi.com/journal/life

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Abstract

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