Decoding the Tumor Microenvironment of Myoepithelial Cells in Triple-Negative Breast Cancer Through Single-Cell and Transcriptomic Sequencing and Establishing a Prognostic Model Based on Key Myoepithelial Cell Genes

Xiaocheng Yu; Ye Tian; Rui Zhang; Yong Yang

doi:10.1155/ijog/6454413

International Journal of Genomics (Jan 2025)

Decoding the Tumor Microenvironment of Myoepithelial Cells in Triple-Negative Breast Cancer Through Single-Cell and Transcriptomic Sequencing and Establishing a Prognostic Model Based on Key Myoepithelial Cell Genes

Xiaocheng Yu,
Ye Tian,
Rui Zhang,
Yong Yang

Affiliations

Xiaocheng Yu: Department of Thyroid and Breast Surgery
Ye Tian: Department of Thyroid and Breast Surgery
Rui Zhang: Department of Thyroid and Breast Surgery
Yong Yang: Department of Thyroid and Breast Surgery

DOI: https://doi.org/10.1155/ijog/6454413
Journal volume & issue: Vol. 2025

Abstract

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Conclusion: This study highlights MECs’ role in TNBC progression, provides a CoxBoost prognostic model for personalized treatment, and identifies TPD52 as a potential therapeutic target for TNBC intervention.

Published in International Journal of Genomics

ISSN: 2314-436X (Print); 2314-4378 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Genetics
Website: https://onlinelibrary.wiley.com/journal/4140

About the journal