Nature Communications (Sep 2019)
Sex-specific transcriptional and proteomic signatures in schizophrenia
- Jari Tiihonen,
- Marja Koskuvi,
- Markus Storvik,
- Ida Hyötyläinen,
- Yanyan Gao,
- Katja A. Puttonen,
- Raisa Giniatullina,
- Ekaterina Poguzhelskaya,
- Ilkka Ojansuu,
- Olli Vaurio,
- Tyrone D. Cannon,
- Jouko Lönnqvist,
- Sebastian Therman,
- Jaana Suvisaari,
- Jaakko Kaprio,
- Lesley Cheng,
- Andrew F. Hill,
- Markku Lähteenvuo,
- Jussi Tohka,
- Rashid Giniatullin,
- Šárka Lehtonen,
- Jari Koistinaho
Affiliations
- Jari Tiihonen
- Department of Clinical Neuroscience, Karolinska Institutet
- Marja Koskuvi
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Markus Storvik
- Department of Pharmacology, University of Eastern Finland
- Ida Hyötyläinen
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Yanyan Gao
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Katja A. Puttonen
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Raisa Giniatullina
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Ekaterina Poguzhelskaya
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Ilkka Ojansuu
- Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital
- Olli Vaurio
- Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital
- Tyrone D. Cannon
- Department of Psychology and Psychiatry, Yale University
- Jouko Lönnqvist
- Mental Health Unit, Department of Public Health Solutions, National Institute for Health and Welfare
- Sebastian Therman
- Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare
- Jaana Suvisaari
- Mental Health Unit, Department of Public Health Solutions, National Institute for Health and Welfare
- Jaakko Kaprio
- Department of Public Health, University of Helsinki
- Lesley Cheng
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Andrew F. Hill
- Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University
- Markku Lähteenvuo
- Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital
- Jussi Tohka
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Rashid Giniatullin
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Šárka Lehtonen
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- Jari Koistinaho
- A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland
- DOI
- https://doi.org/10.1038/s41467-019-11797-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Noise due to genetic heterogeneity potentially impacts the the discovery of genes that contribute to diseases such as schizophrenia (SCZ). In this study, authors minimize the disease-irrelevant noise between SCZ and healthy individuals by profiling transcriptional signatures among discordant monozygotic twin pairs, and demonstrate that although sexes share many of the final common pathways, the underlying primary pathophysiology of SCZ differs between males and females.
