Nature Communications (Apr 2019)

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation

  • Kei Miyakawa,
  • Satoko Matsunaga,
  • Masaru Yokoyama,
  • Masako Nomaguchi,
  • Yayoi Kimura,
  • Mayuko Nishi,
  • Hirokazu Kimura,
  • Hironori Sato,
  • Hisashi Hirano,
  • Tomohiko Tamura,
  • Hirofumi Akari,
  • Tomoyuki Miura,
  • Akio Adachi,
  • Tatsuya Sawasaki,
  • Naoki Yamamoto,
  • Akihide Ryo

DOI
https://doi.org/10.1038/s41467-019-09867-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The accessory lentiviral protein X (Vpx) of the SIVsmm/mac and HIV-2 lineage targets the host-restriction factor SAMHD1 for proteasomal degradation. Here, the authors show that host PIM kinase-mediated phosphorylation of Vpx stabilizes its interaction with SAMHD1, suggesting PIM as potential antiviral targets.