Nature Communications (Oct 2019)
High-potency ligands for DREADD imaging and activation in rodents and monkeys
- Jordi Bonaventura,
- Mark A. G. Eldridge,
- Feng Hu,
- Juan L. Gomez,
- Marta Sanchez-Soto,
- Ara M. Abramyan,
- Sherry Lam,
- Matthew A. Boehm,
- Christina Ruiz,
- Mitchell R. Farrell,
- Andrea Moreno,
- Islam Mustafa Galal Faress,
- Niels Andersen,
- John Y. Lin,
- Ruin Moaddel,
- Patrick J. Morris,
- Lei Shi,
- David R. Sibley,
- Stephen V. Mahler,
- Sadegh Nabavi,
- Martin G. Pomper,
- Antonello Bonci,
- Andrew G. Horti,
- Barry J. Richmond,
- Michael Michaelides
Affiliations
- Jordi Bonaventura
- Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program
- Mark A. G. Eldridge
- Laboratory of Neuropsychology, National Institute of Mental Health Intramural Research Program
- Feng Hu
- Department of Radiology Johns Hopkins School of Medicine
- Juan L. Gomez
- Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program
- Marta Sanchez-Soto
- Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke Intramural Research Program
- Ara M. Abramyan
- Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program
- Sherry Lam
- Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program
- Matthew A. Boehm
- Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program
- Christina Ruiz
- Department of Neurobiology & Behavior, University of California
- Mitchell R. Farrell
- Department of Neurobiology & Behavior, University of California
- Andrea Moreno
- Department of Molecular Biology and Genetics, Dandrite, Aarhus University
- Islam Mustafa Galal Faress
- Department of Molecular Biology and Genetics, Dandrite, Aarhus University
- Niels Andersen
- Department of Molecular Biology and Genetics, Dandrite, Aarhus University
- John Y. Lin
- School of Medicine, College of Health and Medicine, University of Tasmania
- Ruin Moaddel
- Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program
- Patrick J. Morris
- National Center for Advancing Translational Sciences
- Lei Shi
- Computational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program
- David R. Sibley
- Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke Intramural Research Program
- Stephen V. Mahler
- Department of Neurobiology & Behavior, University of California
- Sadegh Nabavi
- Department of Molecular Biology and Genetics, Dandrite, Aarhus University
- Martin G. Pomper
- Department of Radiology Johns Hopkins School of Medicine
- Antonello Bonci
- Synaptic Plasticity Section, National Institute on Drug Abuse Intramural Research Program
- Andrew G. Horti
- Department of Radiology Johns Hopkins School of Medicine
- Barry J. Richmond
- Laboratory of Neuropsychology, National Institute of Mental Health Intramural Research Program
- Michael Michaelides
- Biobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program
- DOI
- https://doi.org/10.1038/s41467-019-12236-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREADD radiotracer for imaging purposes.
