In vitro activity of clindamycin, doxycycline, and trimethoprim/sulfamethoxazole against clinical isolates of β-hemolytic Streptococcus spp. via BD Phoenix and broth microdilution

Christian Cho; Ryan K Shields; Ellen G Kline; Thomas L. Walsh; Chelsea E. Jones; Karen Kasarda; Kelly Stefano; Matthew A. Moffa; Derek N. Bremmer

doi:10.1017/ash.2023.515

Antimicrobial Stewardship & Healthcare Epidemiology (Jan 2023)

In vitro activity of clindamycin, doxycycline, and trimethoprim/sulfamethoxazole against clinical isolates of β-hemolytic Streptococcus spp. via BD Phoenix and broth microdilution

Christian Cho,
Ryan K Shields,
Ellen G Kline,
Thomas L. Walsh,
Chelsea E. Jones,
Karen Kasarda,
Kelly Stefano,
Matthew A. Moffa,
Derek N. Bremmer

Affiliations

Christian Cho: Department of Pharmacy, Allegheny Health Network, Pittsburgh, PA, USA
Ryan K Shields: Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA XDR Pathogens Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Ellen G Kline: Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Thomas L. Walsh: Division of Infectious Diseases, Allegheny Health Network, Pittsburgh, PA, USA
Chelsea E. Jones: Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Karen Kasarda: Department of Pathology and Laboratory Medicine, Allegheny Health Network, Pittsburgh, PA, USA
Kelly Stefano: Department of Pathology and Laboratory Medicine, Allegheny Health Network, Pittsburgh, PA, USA
Matthew A. Moffa: ORCiD; Division of Infectious Diseases, Allegheny Health Network, Pittsburgh, PA, USA
Derek N. Bremmer: ORCiD; Department of Pharmacy, Allegheny Health Network, Pittsburgh, PA, USA

DOI: https://doi.org/10.1017/ash.2023.515
Journal volume & issue: Vol. 3

Abstract

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We tested 85 isolates of β-hemolytic Streptococcus spp. against trimethoprim/sulfamethoxazole (TMP/SMX), clindamycin, and doxycycline by broth microdilution (BMD) and BD Phoenix. Susceptibility rates via BMD for TMP/SMX, clindamycin, and doxycycline were 100%, 85.5%, and 56.6%, respectively. TMP/SMX is a potential monotherapy agent for β-hemolytic Streptococcus skin and soft tissue infections.

Published in Antimicrobial Stewardship & Healthcare Epidemiology

ISSN: 2732-494X (Online)
Publisher: Cambridge University Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.cambridge.org/core/journals/antimicrobial-stewardship-and-healthcare-epidemiology

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