Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

John P. Barton; Nilu Goonetilleke; Thomas C. Butler; Bruce D. Walker; Andrew J. McMichael; Arup K. Chakraborty

doi:10.1038/ncomms11660

Nature Communications (May 2016)

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable

John P. Barton,
Nilu Goonetilleke,
Thomas C. Butler,
Bruce D. Walker,
Andrew J. McMichael,
Arup K. Chakraborty

Affiliations

John P. Barton: Ragon Institute of MGH, MIT and Harvard
Nilu Goonetilleke: Department of Microbiology, Immunology and Medicine, University of North Carolina
Thomas C. Butler: Department of Chemical Engineering, Massachusetts Institute of Technology
Bruce D. Walker: Ragon Institute of MGH, MIT and Harvard
Andrew J. McMichael: Nuffield Department of Medicine, University of Oxford
Arup K. Chakraborty: Ragon Institute of MGH, MIT and Harvard

DOI: https://doi.org/10.1038/ncomms11660
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al. combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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